In Day Two of an exclusive interview with The Sun, Madonna branded the legendary fashion designer Karl Lagerfeld's comments "horrible" and "ridiculous".
Last month, the eccentric Chanel designer claimed Tottenham-born Adele was "a little too fat" when he guest-edited a French magazine.
But Madonna, 53, stuck up for the Grammy-winner, hitting back: "That's horrible. That's ridiculous, that's just the most ridiculous thing I've ever heard.
"I don't like it when anybody says anything bad about anyone — I don't like it. Adele's a great talent and how much she weighs has nothing to do with it."
Madonna, who has won seven Grammys and two Brit awards, explained how she has sustained a career in music spanning more than a quarter of a century — and said it is decent advice for Adele, 23, to stay on the right track.
She said: "The thing for Adele to remember is at the end of the day, whether you rise or fall, it has so much to do with how you sustain yourself and keep your integrity and your inner strength.
"It is all about who you surround yourself with — friends and people who really do care about you, and care about your well-being beyond being a superstar. That's the most important thing."

Part two of The Sun interview is now online, click HERE to read the rest!