PerezHilton.com has learned exclusively that Madonna and Demi Moore will once again be co-hosting an Oscar after-party!

The party will take place at Madge's manager Guy Oseary's home at 10 p.m. after the awards.

Guests expected to be in attendance include Natalie Portman, Colin Firth, Justin Timberlake, Nicole Kidman, David Fincher, and many, many more!

Sounds like it should be one HELL of a party!